G1, in which participants received a 10-day course of rifaximin (1,200 mg) followed by a 24-day course of a nutraceutical containing Bifidobacterium longum W11, soluble fiber, and vitamins B 1, B 2, B 6, and B 12. Participants were randomized to 3 groups: DesignĪ nonblinded, prospective, randomized, controlled clinical study. The aim of this study was to compare rifaximin followed by a nutraceutical or low–fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet to stand-alone therapy with a spore-based probiotic (MegaSporeBiotic) in patients with irritable bowel syndrome (IBS) without constipation. spores-a promising treatment option for patients with irritable bowel syndrome. ReferenceĬatinean A, Neag AM, Nita A, Buzea M, Buzoianu AD. Book in with your functional medicine practitioner to see which option is best suited for your specific health goals.This article is part of our May 2020 special issue. In conclusion, individuality always determines which type of probiotic you may need as there are specific mechanisms both spore based and regular strains possess. Other benefits of spore-based probiotics include: In contrast, Bacillus strains are gram positive bacteria and have been shown in research to reduce endotoxin load by 42% in just 30 days of supplementation. Spore-based probiotics are beneficial in the presence of intestinal hyperpermeability aka “leaky gut”, this is because leaky gut has been correlated with excessive amounts of gram negative bacteria in the gut which produce endotoxins. Further, the endospore allows the bacteria to remain dormant until there is a hospitable environment where it is needed. Unlike regular probiotics, spore-based contain an “endospore”, meaning it contains a protective layer that allows it to safely travel through the entire digestive tract. Some strains of spore based probiotics include: Soil-based probiotics, which are also called spore based, are as the name suggests – found in the soil! Historically, we were exposed to soil based strains from naturally eating produce with soil residual and walking bare foot on the dirt more frequently like our ancestors did. In this instance probiotics can worsen symptoms such as bloating and distention due to the overgrowth of Lactobacillus and Bifidobacterium in the small intestine producing methane or hydrogen. Whilst probiotic food and supplements can be beneficial in certain circumstances, if you find yourself reacting to them, it may be due to a common condition called small intestinal bacterial overgrowth aka SIBO. Regular probiotics are strains which naturally occur in our body and can be found in foods such as yogurt, sauerkraut, kimchi, kombucha and kefir. Some of the most common strains of regular probiotics are: So where does spore based probiotics come in? First, let’s look at the regular strains.
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